It is classified as a pyrophosphate analog dna polymerase inhibitor. Composicion, indicaciones, presentacion y contraindicaciones. Penciclovir, ganciclovir, trifluridina, idoxiuridina y vidarabina. Foscarnet is a synthetic organic analog of inorganic pyrophosphate with activity against several types of viruses, but primarily used for the treatment of cytomegalovirus retinitis. Antivirales universidad centroccidental lisandro alvarado. Clinically, foscarnet is employed almost exclusively to treat infections with cytomegalovirus cmv particularly when ganciclovir cannot be used and acyclovirresistant herpes simplex virus hsv and varicella zoster virus vzv. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Foscarnet fda prescribing information, side effects and uses. Foscavir has the potential to chelate divalent metal ions, such as calcium and magnesium, to form stable coordination compounds. Sulfametoxazol, aciclovir, ganciclovir, alopurinol, norfloxacino. Foscarnet efectos secundarios, dosificacion, interacciones. A type of abnormal heartbeat prolonged qt interval has happened with foscarnet.
Foscarnet is superior to vidarabine in the treatment of acyclovirresistant hsv infections in patients with aids, and remains a treatment of choice for this illness at a dose of 40 mgkg three times daily 96. Pdf topical treatment of recurrent genital herpes simplex. Topical treatment of recurrent genital herpes simplex virus infections with trisodium phosphonoformate foscarnet. Pdf nefrotoxicidad inducida por medicamentos researchgate. Foscarnet sodico dosificacion, efectos secundarios infosida. Foscarnet sodium has the potential to chelate divalent metal ions, such as calcium and magnesium, to form stable coordination compounds. Foscarnet richet indicaciones, dosificacion, presentacion. Administracion oral, tambien im, sc,ev, concentracion en hematies, eliminacion lenta efectos adversos.
Foscarnet selectively blocks the pyrophosphate binding site of virusspecific dna polymerases at concentrations that do not affect cellular dna polymerases. Jan 26, 2020 a type of abnormal heartbeat prolonged qt interval has happened with foscarnet. Foscarnet sodium is a white, crystalline powder containing 6 equivalents of water of hydration with an empirical formula of na3co5p6 h20 and a molecular weight of 300. Foscarnet sodico appare come una polvere cristallina biancastra contenente 6 equivalenti di acqua di idratazione e formula molecolare na3co5p 6 h2o di peso molecolare pari a a 300,1 grammi mole. Foscarnet phosphonomethanoic acid is an antiviral medication which is primarily used to treat viral infections involving the herpesviridae family. Foscarnet phosphonomethanoic acid, known by its brand name foscavir, is an antiviral medication which is primarily used to treat viral infections involving the herpesviridae family. Call your doctor right away if you have a fast or abnormal heartbeat, or if you pass out. Double blind, placebo controlled, multicentre study. Low white blood cell counts have happened with foscarnet.
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